For years, we’ve treated chronic inflammation, allergies, autoimmune disease, and immune dysfunction as separate problems. But it’s becoming clearer that many of these conditions share a common root hiding in plain sight: the gut microbiome.
We now understand that the microbes living inside us shape immune tolerance, inflammation, and long-term disease risk, and even how well medications work.
But despite hundreds of thousands of microbiome studies, most clinicians and patients are still operating in the dark. Because the microbiome isn’t just complex; it’s too complex for the human brain alone.
No clinician can synthesize hundreds of thousands of studies, track millions of microbial data points, and simultaneously account for diet, fiber, sleep, stress, exercise, antibiotics, and immune signaling. That’s where AI-driven platforms like Jona come in.
It can now analyze massive microbiome datasets across hundreds of thousands of studies, and translate that complexity into individualized, actionable insight. We can use it to detect immune-risk patterns early and model lifestyle interventions before they’re ever implemented.
How can we use AI to detect immune-risk patterns early and model lifestyle interventions before they’re ever implemented? How might AI change the way we diagnose and test for immune dysfunction, long before disease becomes obvious?
What happens when microbiome data and AI-guided lifestyle interventions start working together, instead of in isolation?
In this episode, I’m joined by medical AI pioneer and founder of Jona Health, Dr. Leo Grady. He has spent decades building machine-learning systems for medicine and is now applying that same rigor to the gut microbiome.
We talk about how his platform reads the entire body of microbiome science, detects immune-risk signatures before symptoms ever appear, and simulates lifestyle interventions before a person makes a single change.
The good news about the gut microbiome is that it can be changed through different lifestyle interventions. -Dr. Leo Grady
Things You’ll Learn In This Episode
AI turns lifestyle advice into precision medicine
Diet, fiber, exercise, sleep, stress, and supplements all change the microbiome, but not in the same way for everyone. How does Jona allow people to test interventions virtually before trying them in real life?
More probiotics aren’t always better
Some microbes have a “sweet spot,” not a simple more-is-better rule. How often are well-meaning supplements pushing people in the wrong direction?
The future of prevention may start in the gut, not the clinic
From allergies to biologics to chronic disease management, the microbiome may soon guide treatment selection itself. Will AI-powered gut testing become as routine as blood work?
About my Guest
Leo Grady, PhD, is the founder and CEO of Jona, a health technology company that utilizes artificial intelligence to analyze the gut microbiome and provide personalized health insights. Leo is an internationally recognized AI and healthcare innovator with over 20 years of experience, known for leading the development of FDA-approved AI technologies in pathology, cardiology, radiology, and now spearheading microbiome-based health solutions at Jona. To learn more, visit jona.health and follow @jonahealth.
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